NAD+ metabolism influences TGF-β–associated transcriptional programs and the gut microbiota in murine models of colitis
Hisayuki Amano, Akiyoshi Komuro, Kazushige Ota, Masahiko Honda, Kazuko Sakai, Kazuto Nishio, Takeshi Ueda, Hitoshi Okada · 2026
Read NAD+ metabolism influences TGF-β–associated transcriptional programs and the gut microbiota in murine models of colitis by Hisayuki Amano, Akiyoshi Komuro, Kazushige Ota, Masahiko Honda, Kazuko Sakai, Kazuto Nishio, Takeshi Ueda, Hitoshi Okada (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13505500.txt.
Description
Hisayuki Amano and co-authors study how a cell fuel called NAD+ shapes gut inflammation in mice, in a 2026 paper. NAD+ helps cells keep balance, and its loss has been tied to scarring diseases, among them bowel inflammation. The team fed mice a building block of NAD+ called NMN and watched gene programs tied to a growth signal that drives scarring.
In mouse cells grown in dishes, NMN partly undid gene changes caused by that signal, including shifts in genes tied to repair and scarring. In mice with induced colitis, the same broad pattern appeared, and gut bacteria shifted as well. Long-term dosing changed immune gene patterns in the colon. The work links cell fuel, gene control, and gut microbes in bowel disease.
Catalog record
| CREATOR | Hisayuki Amano, Akiyoshi Komuro, Kazushige Ota, Masahiko Honda, Kazuko Sakai, Kazuto Nishio, Takeshi Ueda, Hitoshi Okada |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |