From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late life
David Lukacsovich, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Wei Zhang, Brian W. Kunkle, Xi Steven Chen, Eden R. Martin, Lily Wang · 2026
Read From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late life by David Lukacsovich, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Wei Zhang, Brian W. Kunkle, Xi Steven Chen, Eden R. Martin, Lily Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13505181.txt.
Description
David Lukacsovich and co-authors asked how closely chemical marks on brain DNA track both normal ageing and Alzheimer's disease. They combined post-mortem tissue data from two cohorts covering the front part of the brain. Analyses adjusted for nerve cell share, sex, and technical batch before the two cohorts were merged.
More than three thousand sites changed with age, most gaining marks, and they clustered near gene control regions tied to immunity and metabolism. Nearly all sites shared with Alzheimer's-related brain changes moved in the same direction in both conditions. Brains from people with Alzheimer's also showed faster chemical ageing than brains from unimpaired donors. One site, near a gene called AZU1, linked with later decline in a separate living cohort. The work frames ageing marks as a large part of the chemical ageing seen in Alzheimer's.
Catalog record
| CREATOR | David Lukacsovich, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Wei Zhang, Brian W. Kunkle, Xi Steven Chen, Eden R. Martin, Lily Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74514 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |