Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism
Yosra Gassara, Hajer Foddha, Saoussen Chouchene, Sarra Nasri, Rim Kallala, Amel Haj Khelil, Mohsen Hassin, Hassen Ben Abdennebi, Belhassen Harzallah · 2026
Read Analysis of genetic polymorphisms and mRNA expression of DRD3 and HTR2A in bruxism by Yosra Gassara, Hajer Foddha, Saoussen Chouchene, Sarra Nasri, Rim Kallala, Amel Haj Khelil, Mohsen Hassin, Hassen Ben Abdennebi, Belhassen Harzallah (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13505174.txt.
Description
Yosra Gassara and others analyze genetic polymorphisms and gene levels of DRD3 and HTR2A in bruxism. In 2026, the case-control study covers eighty-two bruxism patients and eighty-seven controls, genotyping two variants and testing peripheral blood messenger RNA. Bruxism, involuntary grinding or clenching, reflects genetic, mental, and environmental influences.
The HTR2A rs6313 variant linked clearly with bruxism, with the C allele raising risk about 1.89-fold, and HTR2A levels was upregulated in patients. DRD3 genotype did not differ clearly, though its C allele appeared to raise sleep bruxism susceptibility and its levels was downregulated. Mood signal and drive signal pathways thus appear involved in bruxism, aiding early finding and aimed treatment research.
Catalog record
| CREATOR | Yosra Gassara, Hajer Foddha, Saoussen Chouchene, Sarra Nasri, Rim Kallala, Amel Haj Khelil, Mohsen Hassin, Hassen Ben Abdennebi, Belhassen Harzallah |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |