Vacuum-stabilized lung window enables real-time and simultaneous imaging of vascular and calcium responses to hypoxia in vivo
Jie Liu, Junyan Shao, Pu Liao, Xinyu Song, Wenbo Yang, Chenlong Yu, Rui Xiao, Liping Zhu, Qinghua Hu · 2026
Read Vacuum-stabilized lung window enables real-time and simultaneous imaging of vascular and calcium responses to hypoxia in vivo by Jie Liu, Junyan Shao, Pu Liao, Xinyu Song, Wenbo Yang, Chenlong Yu, Rui Xiao, Liping Zhu, Qinghua Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13505155.txt.
Description
Jie Liu and colleagues built a vacuum-stabilised window that lets researchers watch living mouse lungs under a microscope while the animal keeps breathing. Earlier methods blurred or could not follow vessel movement and cell signals together. Their setup combines two-photon imaging, glowing tracers in the blood, and a calcium sensor placed only in vessel-wall muscle cells.
When oxygen dropped for thirty minutes, small lung arteries narrowed over time, shrinking about eight percent in mid-sized vessels. Calcium signals inside the muscle cells rose before each narrowing, with the earliest responses in the smallest arteries watched. A drug called dasatinib delayed the calcium response and changed its rhythm, mainly in mid-sized vessels. The platform gives physiologists a direct view of how lung vessels sense low oxygen, a reaction that can turn harmful in lung hypertension.
Catalog record
| CREATOR | Jie Liu, Junyan Shao, Pu Liao, Xinyu Song, Wenbo Yang, Chenlong Yu, Rui Xiao, Liping Zhu, Qinghua Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37020 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |