ST2 blockade modulates IL-33–driven immune responses and is associated with reduced hepatic fibrosis in alveolar echinococcosis
Emad Shamsan, Liu Chuanchuan, Fan Haining · 2026
Read ST2 blockade modulates IL-33–driven immune responses and is associated with reduced hepatic fibrosis in alveolar echinococcosis by Emad Shamsan, Liu Chuanchuan, Fan Haining (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13505141.txt.
Description
Emad Shamsan and co-authors studied a severe parasitic liver disease caused by the tapeworm Echinococcus multilocularis, which grows into liver tissue and scars it over time. They focused on a signalling pair, the protein IL-33 and its receptor ST2, and asked whether blocking ST2 changes the course of infection. Work combined liver tissue from patients with a mouse model of the disease.
Patient tissue showed raised IL-33 and ST2 alongside markers of immune activity and scarring. In infected mice, blocking ST2 shrank parasite lesions and reduced liver invasion. Treated livers carried less scar tissue, fewer gathered immune cells, and lower levels of several inflammatory signals in the blood. Because parasite burden also fell, the authors note that further work must separate direct anti-scarring effects from effects that follow from controlling the parasite.
Catalog record
| CREATOR | Emad Shamsan, Liu Chuanchuan, Fan Haining |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38062 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |