Boerhaave’s syndrome associated with glucagon-like peptide-1 receptor agonist use: a case report
Jason M Aubrey, Chance Benner, Geoffrey T Lam · 2026
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Description
Jason M Aubrey and colleagues describe a woman in her fifties who suffered a full-thickness tear of the esophagus after restarting the weight-loss drug semaglutide. She had been off the drug for months and resumed at the highest weekly dose without building up gradually. Within a day she developed severe vomiting, chest pain, shock, and breathing failure.
Scans showed air around the heart and fluid around both lungs, and a swallow study confirmed the perforation. Doctors treated her with an endoscopic stent, chest drainage, and tube feeding, and she improved enough to go home. Two months later she returned with a severe lung infection and a fistula, needing major chest surgery. At ten months she ate normally with the esophagus healed, and the authors warn clinicians to suspect this rare injury when vomiting and chest pain follow a restart.
Catalog record
| CREATOR | Jason M Aubrey, Chance Benner, Geoffrey T Lam |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20189 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |