Insomnia, proteomic characteristics, and mortality risk in depression: a UK Biobank study
Xuesong Liu, Hongli Xu, Xiaoqian Zhu, Jiabin Tu, Kaiyang Lin, Yansong Guo · 2026
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Description
Xuesong Liu leads a team linking insomnia to higher death risk in people with depression, and tracing part of that path through blood proteins, in a 2026 UK Biobank study. Sleeplessness is near universal in depression and has been tied to worse outcomes, but the biology in between was blank.
Among nearly four and a half thousand depressed participants, those who usually had insomnia faced about a third higher death risk and lost over two years of life expectancy at age forty-five. A signature of twenty sleeplessness-linked proteins carried its own risk signal. Joint analysis credited the protein set with over a third of the insomnia effect, with three proteins standing as solo mediators. The signature also improved risk forecasts past standard clinical factors.
Catalog record
| CREATOR | Xuesong Liu, Hongli Xu, Xiaoqian Zhu, Jiabin Tu, Kaiyang Lin, Yansong Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53700 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |