From metabolic dysregulation to clinical alert: a novel panel of biomarkers for staging alcohol-associated liver disease
Haonan Gao, Xiaojia Zhang, Lugao Tian, Zilu Cheng, Wenkang Gao, Ye Yang, Zexuan Li, Jiake Che, Yuanqing Zhu, Yupin Tan, Yue Yang, Xinyang Wang, Shuyan Wang, Yonggang Yuan, Zhuang Cao, Yunfei Zhao, Xiaotong Du, Jiahao Liu, Nanfei Liao, Yue Chen, Shengqi Yan, Ling Yang, Lu Jiang, Xiaohua Hou, Keshu Xu, Yuhu Song, Huikuan Chu · 2026
Read From metabolic dysregulation to clinical alert: a novel panel of biomarkers for staging alcohol-associated liver disease by Haonan Gao, Xiaojia Zhang, Lugao Tian, Zilu Cheng, Wenkang Gao, Ye Yang, Zexuan Li, Jiake Che, Yuanqing Zhu, Yupin Tan, Yue Yang, Xinyang Wang, Shuyan Wang, Yonggang Yuan, Zhuang Cao, Yunfei Zhao, Xiaotong Du, Jiahao Liu, Nanfei Liao, Yue Chen, Shengqi Yan, Ling Yang, Lu Jiang, Xiaohua Hou, Keshu Xu, Yuhu Song, Huikuan Chu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13505100.txt.
Description
Haonan Gao leads a team building a blood metabolite panel that stages alcohol-related liver disease, in a 2026 study. The disease runs from heavy drinking through inflamed liver to cirrhosis, and telling stages apart early guides care. Biopsy is invasive, so a blood test would help.
The study enrolled 161 people across healthy, alcohol use disorder, hepatitis, and cirrhosis groups. Chemical profiling of blood found profiles that separated stage by stage. Five metabolites alone told cirrhosis from healthy with near-perfect accuracy in checks. Adding a routine liver enzyme pushed accuracy higher still. A second panel split cirrhosis from inflamed liver perfectly in its test set. The authors offer the panels as a base for risk sorting in clinic.
Catalog record
| CREATOR | Haonan Gao, Xiaojia Zhang, Lugao Tian, Zilu Cheng, Wenkang Gao, Ye Yang, Zexuan Li, Jiake Che, Yuanqing Zhu, Yupin Tan, Yue Yang, Xinyang Wang, Shuyan Wang, Yonggang Yuan, Zhuang Cao, Yunfei Zhao, Xiaotong Du, Jiahao Liu, Nanfei Liao, Yue Chen, Shengqi Yan, Ling Yang, Lu Jiang, Xiaohua Hou, Keshu Xu, Yuhu Song, Huikuan Chu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43891 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |