EYA1 regulates CIITA phosphorylation to promote EYA1–CIITA–Runx2 complex formation and extracellular matrix integrity in osteoarthritis
Guanghua Nie, Yi Li, Hongmou Zhao, Dong Wang, Yan Zhang, Xinquan Yang, Xiaodong Wen · 2026
Read EYA1 regulates CIITA phosphorylation to promote EYA1–CIITA–Runx2 complex formation and extracellular matrix integrity in osteoarthritis by Guanghua Nie, Yi Li, Hongmou Zhao, Dong Wang, Yan Zhang, Xinquan Yang, Xiaodong Wen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13505096.txt.
Description
Guanghua Nie leads a team uncovering a three-protein complex that drives cartilage breakdown in osteoarthritis, in a 2026 study. The disease wears down the cushioning matrix in joints and has no drug that halts it. A known matrix-eating switch, Runx2, lacked a named partner crew until now.
From arthritic mouse cartilage, the team fished out two proteins bound to Runx2: EYA1 and CIITA. Together the three sit on the start lines of the main matrix-chewing genes and switch them on. Silencing any one member cut those genes sharply. EYA1 also strips a phosphate tag from CIITA at one spot, a step set by another enzyme under inflammatory attack. The authors propose blocking this crew as a route to protect joint cartilage.
Catalog record
| CREATOR | Guanghua Nie, Yi Li, Hongmou Zhao, Dong Wang, Yan Zhang, Xinquan Yang, Xiaodong Wen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70545 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |