IsoformSwitchAnalyzeR v2: analysis of functional isoform changes in long-read and single-cell sequencing data
Chunxu Han, Jeroen Gilis, Elena Iriondo Delgado, Lieven Clement, Kristoffer Vitting-Seerup · 2026
Read IsoformSwitchAnalyzeR v2: analysis of functional isoform changes in long-read and single-cell sequencing data by Chunxu Han, Jeroen Gilis, Elena Iriondo Delgado, Lieven Clement, Kristoffer Vitting-Seerup (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13504270.txt.
Description
Chunxu Han and co-authors published a software paper in 2026 on version two of a tool that finds switches in gene transcript use. One gene can make many transcript forms through splicing, and which form dominates can shift with health or disease. The original tool found such switches and judged their effects. New long-read and single-cell methods called for an update.
Version two detects switches more robustly and adds new types of functional notes. It also works better with other bioinformatics tools. Two case studies show the standard workflow on long-read data from Alzheimer patients and single-cell data from brain tumor patients. Both found switches with effects tied to the disease.
Catalog record
| CREATOR | Chunxu Han, Jeroen Gilis, Elena Iriondo Delgado, Lieven Clement, Kristoffer Vitting-Seerup |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |