Preclinical evaluation of a fluorine-18-labeled indocyanine green analog for PET imaging of hepatic function
Khashayar Vakili, Alan Packard · 2026
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Description
Khashayar Vakili and Alan Packard test a radioactive form of a liver dye for PET scans, in a 2026 animal study. Doctors judge liver health by how fast the dye indocyanine green clears from blood, but its glow cannot be read deep in the body. A PET version could map liver function directly.
The team tagged the dye with fluorine-18 and injected it into animals. Scans showed fast liver uptake, peaking in about twenty minutes, then brisk flow into the gallbladder and gut, as with the plain dye. Kidney uptake stayed low, and no ill effects showed over four hours. Yield of the tagging step was low, so the team lists yield gains and safety tests as next steps before human use.
Catalog record
| CREATOR | Khashayar Vakili, Alan Packard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29050 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |