Phosphoproteomic profiling reveals reversal of dysregulated kinase signaling by nitric oxide inhibition in the Shank3 mouse model of autism
Shelly Ginzburg, Igor Khaliulin, Maryam Kartawy, Wajeha Hamoudi, Haitham Amal · 2026
Read Phosphoproteomic profiling reveals reversal of dysregulated kinase signaling by nitric oxide inhibition in the Shank3 mouse model of autism by Shelly Ginzburg, Igor Khaliulin, Maryam Kartawy, Wajeha Hamoudi, Haitham Amal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13503915.txt.
Description
Shelly Ginzburg and four colleagues probe how nitric oxide signaling rewires protein switches in a mouse model of autism, in a 2026 study. The model lacks part of the Shank3 gene, a high-risk gene for autism. Past work showed excess nitric oxide in these mice, and blocking its making eased their traits.
The team read the full protein set and its phosphate tags in brain cortex tissue. Mutant mice showed shifted tags on proteins tied to synapses, growth, and RNA handling. A drug that blocks the nitric oxide enzyme flipped many of those shifts back. Several high-risk autism genes were among the proteins restored. The work ties nitric oxide to the kinase web that sets those tags, and hints at new drug targets.
Catalog record
| CREATOR | Shelly Ginzburg, Igor Khaliulin, Maryam Kartawy, Wajeha Hamoudi, Haitham Amal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62381 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |