Comparative in vitro and in vivo assessment of three experimental extracellular matrix meshes for soft tissue remodeling
Wenting Ruan, Guowei Wang, Qiujin Qu, Xiaoxiao Gai, Changbin Wang, Jia Liu, Fuyu Zhu, Zhonghua Qu, Chenghu Liu · 2026
Read Comparative in vitro and in vivo assessment of three experimental extracellular matrix meshes for soft tissue remodeling by Wenting Ruan, Guowei Wang, Qiujin Qu, Xiaoxiao Gai, Changbin Wang, Jia Liu, Fuyu Zhu, Zhonghua Qu, Chenghu Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13503870.txt.
Description
Wenting Ruan and others compare three test meshes of outside-cell matrix for soft tissue remodeling. In 2026, the study builds a same-form cross-species plan testing human acellular dermis, porcine acellular dermis, and porcine small intestinal submucosa. Testing runs through lab characterization and rabbit under the skin plus rat belly defect models. Mesh performance varies sharply by tissue source, yet no common review standard existed.
Human dermis proved most stable, retaining 82.3 percent mass after seven days of collagenase digestion, while intestinal submucosa degraded fastest and provoked severe foreign body reactions. Human dermis uniquely sustained healing-type M2 eater cell dominance, reducing swelling and improving collagen remodeling. Implantation also reprogrammed host amino acid fuel use, notably methionine pathways.
Catalog record
| CREATOR | Wenting Ruan, Guowei Wang, Qiujin Qu, Xiaoxiao Gai, Changbin Wang, Jia Liu, Fuyu Zhu, Zhonghua Qu, Chenghu Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |