Association of UACR and UPCR with kidney failure: analysis of observational data in children with chronic kidney disease
Murunga Sheila, Jonas Hofstetter, Aysun K Bayazit, Ali Duzova, Lukasz Obrycki, Anke Doyon, Justine Bacchetta, Rukshana Shroff, Julia Thumfart, Francesca Lugani, Jerome Harambat, Anette Melk, Uwe Querfeld, Franz Schaefer · 2026
Read Association of UACR and UPCR with kidney failure: analysis of observational data in children with chronic kidney disease by Murunga Sheila, Jonas Hofstetter, Aysun K Bayazit, Ali Duzova, Lukasz Obrycki, Anke Doyon, Justine Bacchetta, Rukshana Shroff, Julia Thumfart, Francesca Lugani, Jerome Harambat, Anette Melk, Uwe Querfeld, Franz Schaefer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13503107.txt.
Description
Sheila Murunga and colleagues compared two urine protein measures head to head in 2026 for predicting progression of chronic kidney disease in children. Both the albumin-based ratio and the total protein ratio are used for risk sorting, but their relative strength was unclear. The study tracked 596 children aged 6 to 17 with moderate to advanced disease, most with congenital kidney and urinary tract anomalies.
A standard-step rise in the albumin ratio came with more than double the risk of the combined bad outcome of halved kidney function, near-total failure, or replacement therapy. The same step in the protein ratio came with a smaller rise. The albumin measure's link was about 28 percent stronger, though the two did not differ on the yearly rate of function decline overall. The authors back current guidance that favors the albumin measure for risk sorting and monitoring.
Catalog record
| CREATOR | Murunga Sheila, Jonas Hofstetter, Aysun K Bayazit, Ali Duzova, Lukasz Obrycki, Anke Doyon, Justine Bacchetta, Rukshana Shroff, Julia Thumfart, Francesca Lugani, Jerome Harambat, Anette Melk, Uwe Querfeld, Franz Schaefer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |