Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi · 2026
Read Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity by Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13502594.txt.
Description
Zhiqiang Xie leads a fifteen-author team reporting a 2026 study of prodrugs designed to switch on STING. That innate immune alarm detects DNA and can be harnessed against tumours. Their carriers are deoxyribose cyclic dinucleotides fitted with esterase masks. Such masks create chiral phosphorus centres, and chirality had never been compared. The team separated three diastereoisomers of an alkyne-tagged prodrug and measured stability, cell entry, and activity head to head.
One shape won everywhere. The (Rp,Rp) form activated STING in THP1 cells at an EC50 of 1.7 nanomolar on the reported assay, with a longer pulse than its siblings. In mice it beat the unmasked compound and the benchmark agonist ADU-S100. Given intravenously against CT26 colon tumours it produced a 90 percent response rate, extended survival, and left immune memory against the tumour. Chirality, the authors conclude, is a design variable STING drug makers ignore at their cost.
Catalog record
| CREATOR | Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41027 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |