Design of a mobile application and evaluation of its effects on clinical outcomes in patients with dry eye disease: a study protocol for a randomized controlled trial
Maryam Edalati Khodabandeh, Razieh Farrahi, Mahdi Sargolzaei, Morteza Mohammadi, Amir Hossein Edalati Khodabandeh, Siamak Zarei-Ghanavati, Saeid Eslami · 2026
Read Design of a mobile application and evaluation of its effects on clinical outcomes in patients with dry eye disease: a study protocol for a randomized controlled trial by Maryam Edalati Khodabandeh, Razieh Farrahi, Mahdi Sargolzaei, Morteza Mohammadi, Amir Hossein Edalati Khodabandeh, Siamak Zarei-Ghanavati, Saeid Eslami (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501860.txt.
Description
Maryam Edalati Khodabandeh leads a seven-author team publishing a 2026 protocol for a randomized trial of a self-care app for dry eye disease. Stage one built the app, with a Python Flask and SQLite back end and a Flutter front end. Stage two is a blinded trial: both groups receive usual care, and the intervention group adds the app for twelve weeks. The main outcome is tear break-up time, a stability test, with a Persian symptom questionnaire as the secondary measure, checked at six and twelve weeks.
The plan targeted 104 patients, yet COVID-19 disruption changed the course: 181 patients were randomized, 91 to the app and 90 to control, and 104 completed. The dropout rate was 42.5 percent across the arms. The team expects tailored training to reduce severity and strengthen the doctor-patient relationship. The trial sits in the Iranian registry under code IRCT20200721048162N1.
Catalog record
| CREATOR | Maryam Edalati Khodabandeh, Razieh Farrahi, Mahdi Sargolzaei, Morteza Mohammadi, Amir Hossein Edalati Khodabandeh, Siamak Zarei-Ghanavati, Saeid Eslami |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22786 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |