Association between different metabolic phenotypes and chronic kidney disease risk: a cohort study
Qi Yu, Haolan Xu, Qin Yang, Wenjing Wang, Ru Zhou, Yanlang Yang · 2026
Read Association between different metabolic phenotypes and chronic kidney disease risk: a cohort study by Qi Yu, Haolan Xu, Qin Yang, Wenjing Wang, Ru Zhou, Yanlang Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501839.txt.
Description
Qi Yu leads a six-author team reporting a 2026 cohort study of how metabolic health and body weight, alone and in motion, predict chronic kidney disease. The study followed 7,034 participants sorted into four phenotypes crossing weight with metabolic status: healthy and non-overweight at 35.6 percent, healthy but overweight at 18.3 percent, unhealthy but non-overweight at 17.5 percent, and unhealthy and overweight at 28.6 percent of the cohort at baseline. New kidney disease meant filtration below threshold or protein in the urine across two straight years.
After adjustment, the unhealthy phenotypes carried the risk: hazard ratios of 1.184 for the non-overweight group and 1.420 for the overweight group on that outcome, while staying metabolically healthy and overweight showed no significant link. Change hurt too: people whose healthy overweight status slid into unhealthy territory faced a hazard ratio of 1.649 against those who stayed lean and healthy.
Catalog record
| CREATOR | Qi Yu, Haolan Xu, Qin Yang, Wenjing Wang, Ru Zhou, Yanlang Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34097 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |