Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients
Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Mariela Guerra-García, Rodrigo José Vargas Rosales, Andrea Mariela Ruano Toledo, Dulce Sofia Ocaña-Garrido, Ismael Lares-Asseff, Oscar Cóbar, Sindy Méndez Soveranis, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda · 2026
Read Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients by Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Mariela Guerra-García, Rodrigo José Vargas Rosales, Andrea Mariela Ruano Toledo, Dulce Sofia Ocaña-Garrido, Ismael Lares-Asseff, Oscar Cóbar, Sindy Méndez Soveranis, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501838.txt.
Description
Lesly Yanira Xajil-Ramos leads a twelve-author team reporting a 2026 pharmacokinetic model of tacrolimus in children with kidney transplants. The drug prevents rejection but has a narrow safe window, and children clear it at wildly different rates. The study analysed 165 whole-blood drug measurements from 51 recipients, all at least six months past transplant, using nonlinear mixed-effects modelling in Monolix. Genetic testing covered CYP3A5, the liver enzyme variant that speeds the drug's breakdown, alongside clinical measures.
A two-compartment model with first-order absorption fitted the data well. The CYP3A5 genotype shifted clearance, kidney function estimates influenced both clearance and the central distribution volume, and older age sped absorption. The authors present the model as groundwork for dose individualization. A child's genes, kidney function, and age could one day set the starting dose instead of trial and error, with blood tests fine-tuning it afterward.
Catalog record
| CREATOR | Lesly Yanira Xajil-Ramos, Jesús Alonso Gándara-Mireles, Mariela Guerra-García, Rodrigo José Vargas Rosales, Andrea Mariela Ruano Toledo, Dulce Sofia Ocaña-Garrido, Ismael Lares-Asseff, Oscar Cóbar, Sindy Méndez Soveranis, Leslie Patrón-Romero, Horacio Almanza-Reyes, Randall Lou-Meda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43985 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |