Gli1⁺ cell aggregates promote type H vessel formation and orchestrate bone defect regeneration
Chao Ma, Yu-Ru Gao, Hao Wang, Bing-Dong Sui, Shan-Shan Huang, Yi Zhang, Lu Liu, Xiao-Hui Zhang, Shu-Juan Xing, Yuan-Yuan Li, Yi-Han Xiao, Ya-Nan Zheng, Li-Heng Ren, Yan Jin, Chen-Xi Zheng, Hao-Kun Xu, Ji Chen · 2026
Read Gli1⁺ cell aggregates promote type H vessel formation and orchestrate bone defect regeneration by Chao Ma, Yu-Ru Gao, Hao Wang, Bing-Dong Sui, Shan-Shan Huang, Yi Zhang, Lu Liu, Xiao-Hui Zhang, Shu-Juan Xing, Yuan-Yuan Li, Yi-Han Xiao, Ya-Nan Zheng, Li-Heng Ren, Yan Jin, Chen-Xi Zheng, Hao-Kun Xu, Ji Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501827.txt.
Description
Chao Ma leads a seventeen-author team reporting a 2026 study of cell aggregates that speed bone defect healing in mice. The aggregates mimic the clumping of cells during embryonic development. The team focused on one skeletal progenitor subset marked by Gli1, cells known to maintain bone. Single-cell RNA sequencing showed the Gli1-high cells expressed genes for bone building, blood vessel growth, and matrix production. Inside bone these cells clustered near the growth region, hugging the bone master switch RUNX2 and the type H blood vessels that couple vessels to bone growth.
The team sorted the Gli1-positive cells and formed them into aggregates. In dishes the aggregates coaxed endothelial cells into tubes through secreted signals. Implanted into mouse thigh-bone defects, they regenerated bone faster than unsorted or Gli1-negative aggregates, by summoning type H vessels. The authors pitch precision-sorted aggregates as a regenerative strategy.
Catalog record
| CREATOR | Chao Ma, Yu-Ru Gao, Hao Wang, Bing-Dong Sui, Shan-Shan Huang, Yi Zhang, Lu Liu, Xiao-Hui Zhang, Shu-Juan Xing, Yuan-Yuan Li, Yi-Han Xiao, Ya-Nan Zheng, Li-Heng Ren, Yan Jin, Chen-Xi Zheng, Hao-Kun Xu, Ji Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64774 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |