Integration of triglyceride-glucose index and biological aging to predict cardiovascular disease risk in cardiovascular–kidney–metabolic syndrome stages 0–3: a multiple prospective cohort study
Runnan Shen, Pinrong Dong, Shuxiang Fang, Zirui Jia, Ayiguli Abudukeremu, Jiexin Li, Kai Huang, Xiaoqin Zuo, Yixuan Ma, Yilin Liu, Kai Huang, Yangxin Chen · 2026
Read Integration of triglyceride-glucose index and biological aging to predict cardiovascular disease risk in cardiovascular–kidney–metabolic syndrome stages 0–3: a multiple prospective cohort study by Runnan Shen, Pinrong Dong, Shuxiang Fang, Zirui Jia, Ayiguli Abudukeremu, Jiexin Li, Kai Huang, Xiaoqin Zuo, Yixuan Ma, Yilin Liu, Kai Huang, Yangxin Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501651.txt.
Description
Runnan Shen and colleagues report a 2026 multi-cohort study that fuses two risk signals, insulin resistance and biological aging, into one predictor of cardiovascular disease. The combined index, TyG-KDM-BA, multiplies the triglyceride-glucose index by a biological age estimate. Participants had cardiovascular-kidney-metabolic syndrome at stages 0 to 3. Data came from 286,864 people in the UK Biobank, 7,237 in China's CHARLS cohort, and 517 hospital patients used for external validation of the main outcome.
Over a median 15.27 years in the UK cohort, 57,896 cardiovascular events occurred. Each standard-deviation rise in the combined index carried a hazard ratio of 1.65 there and 1.25 in the Chinese cohort, and the top quarter of scores faced a hazard ratio of 3.97 against the bottom quarter in the UK data. Discrimination beat older triglyceride-glucose variants, though its area under the curve stayed moderate, near 0.657 to 0.659 across 5 to 15 years.
Catalog record
| CREATOR | Runnan Shen, Pinrong Dong, Shuxiang Fang, Zirui Jia, Ayiguli Abudukeremu, Jiexin Li, Kai Huang, Xiaoqin Zuo, Yixuan Ma, Yilin Liu, Kai Huang, Yangxin Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83306 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |