Dual-targeting VEGF and TNF-α with bispecific antibody eyedrops for synergistic treatment of uveitis
Jie Zhou, Yinqi Chen, Ruochu Guan, Wenchao Cai, Zhiqing Lin, Panxiang Rao, Sisi Chen, Penfeng Gao, Qian Yang, Ying Wu, Yihua Zhu, Biting Zhou, Nanwen Zhang, Juhua Yang, Xiaole Chen · 2026
Read Dual-targeting VEGF and TNF-α with bispecific antibody eyedrops for synergistic treatment of uveitis by Jie Zhou, Yinqi Chen, Ruochu Guan, Wenchao Cai, Zhiqing Lin, Panxiang Rao, Sisi Chen, Penfeng Gao, Qian Yang, Ying Wu, Yihua Zhu, Biting Zhou, Nanwen Zhang, Juhua Yang, Xiaole Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501631.txt.
Description
Jie Zhou leads a fifteen-author team reporting a 2026 nanomedicine study of eyedrops for uveitis, a sight-threatening inflammation inside the eye. Biologic drugs each block one target and need injections into the eye, which carry risks when repeated. Screening identified two disease drivers, VEGF and tumour necrosis factor alpha. The team engineered one bispecific antibody, V5-3, that blocks both at once, then packaged it with a dithiolane molecule into nanoparticles that cross the eye's surface after topical dosing.
Compared with the free antibody, the nanoparticle drops entered cells better, curbed microglial growth and movement, and cut inflammatory cytokine release. In cell and animal models the dual targeting combined anti-inflammatory and anti-vessel-growth effects, easing symptoms and tissue damage in the retina. Toxicity was negligible across the models tested. The authors present the drops as a noninvasive candidate for a disease where delivery is the bottleneck.
Catalog record
| CREATOR | Jie Zhou, Yinqi Chen, Ruochu Guan, Wenchao Cai, Zhiqing Lin, Panxiang Rao, Sisi Chen, Penfeng Gao, Qian Yang, Ying Wu, Yihua Zhu, Biting Zhou, Nanwen Zhang, Juhua Yang, Xiaole Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58492 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |