Perioperative management in a patient with congenital factor VII deficiency following mechanical valve replacement: a case report
Xiaokang Luo, Xue Yang, Tucheng Sun, Xinjian Yan · 2026
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Description
Xiaokang Luo leads a four-author team reporting a 2026 case of valve surgery in a 59-year-old man with congenital factor VII deficiency. The rare inherited bleeding disorder affects roughly one person in 500,000. He needed a mechanical valve replacement, which demands lifelong blood thinning, yet his clotting tests were already abnormal because of the missing factor. The standard INR measure cannot reflect true anticoagulation in such patients, and no guideline covers the pairing. Perioperative bleeding was controlled with recombinant activated factor VII replacement.
After surgery he suffered a cerebral thrombosis, a clot in the brain, and warfarin began. Instead of the usual INR target, the team steered dosing by factor II and factor X activity, aiming for 30 to 45 percent. No bleeding and no further clotting followed. The authors recommend replacement therapy for operative safety and factor-activity monitoring to balance the twin risks in similar cases.
Catalog record
| CREATOR | Xiaokang Luo, Xue Yang, Tucheng Sun, Xinjian Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14787 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |