Liquid biopsies reveal dual compartments of cancer risk from tumor and host-derived mutations
Federica Malighetti, Ivan Civettini, Andrea Aroldi, Alberto Maria Villa, Matteo Villa, Luca Sala, Nicoletta Cordani, Massimiliano Cadamuro, Diego Cortinovis, Rocco Piazza, Luca Mologni, Daniele Ramazzotti · 2026
Read Liquid biopsies reveal dual compartments of cancer risk from tumor and host-derived mutations by Federica Malighetti, Ivan Civettini, Andrea Aroldi, Alberto Maria Villa, Matteo Villa, Luca Sala, Nicoletta Cordani, Massimiliano Cadamuro, Diego Cortinovis, Rocco Piazza, Luca Mologni, Daniele Ramazzotti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13501295.txt.
Description
Malighetti and colleagues argued that blood tests for cancer mutations carry two risk signals, one from the tumor and one from the patient's own blood cells. Their 2026 analysis of Memorial Sloan Kettering data spanned more than nine thousand patients with clonal hematopoiesis data and fifteen hundred with circulating tumor DNA data across solid tumors.
Malighetti found the two mutation sources barely overlapped. Mutations from blood-cell clones, in DNA damage response and gene-control genes such as PPM1D, CHEK2, ATM, and TP53, tracked with worse survival, more spread, and spread patterns to specific sites. Some predicted later blood cancers under treatment pressure. Tumor DNA mutations in classic driver genes mirrored tumor aggressiveness and poor prognosis across cancer types. models in lung adenocarcinoma confirmed each source adds independently, supporting a dual-source view in which throwing out blood-cell mutations as noise throws away risk signals.
Catalog record
| CREATOR | Federica Malighetti, Ivan Civettini, Andrea Aroldi, Alberto Maria Villa, Matteo Villa, Luca Sala, Nicoletta Cordani, Massimiliano Cadamuro, Diego Cortinovis, Rocco Piazza, Luca Mologni, Daniele Ramazzotti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |