Designing potent and immunogenic epitope based peptide vaccine against all serotypes of DENV via structural, physico-chemical and immunoinformatics-based approaches
Aparna Chaudhuri, Bidyut Bandyopadhyay, Buddhadev Mondal, Aniket Sarkar, Sabyasachi Ghosh, Arnim Banerjee, Srijita Ari, Anindya Sundar Panja · 2026
Read Designing potent and immunogenic epitope based peptide vaccine against all serotypes of DENV via structural, physico-chemical and immunoinformatics-based approaches by Aparna Chaudhuri, Bidyut Bandyopadhyay, Buddhadev Mondal, Aniket Sarkar, Sabyasachi Ghosh, Arnim Banerjee, Srijita Ari, Anindya Sundar Panja (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13500829.txt.
Description
Aparna Chaudhuri leads an eight-author team with a 2026 computational design of a peptide vaccine meant to cover all four dengue virus serotypes. Dengue spreads by mosquito bite in the tropics, and the licensed vaccine protects unevenly across serotypes. Working in software, the team screened the viral envelope protein for short fragments, called epitopes, that the immune system can recognize. Candidate fragments between 45 and 65 amino acids were checked for immune visibility, allergy risk, and toxicity before assembly into one construct.
The final construct scored 0.7991 on an antigenicity scale and was predicted non-allergenic and non-toxic. Docking showed it binding strongly to immune receptors TLR2 and TLR3 and to antibody chains, with energies near minus 13.9 to minus 11.3 kilocalories per mole. Simulated immune responses showed raised B-cell and T-cell activity, and codon optimization suggested the construct could be produced in E. coli. Laboratory and animal testing remain ahead.
Catalog record
| CREATOR | Aparna Chaudhuri, Bidyut Bandyopadhyay, Buddhadev Mondal, Aniket Sarkar, Sabyasachi Ghosh, Arnim Banerjee, Srijita Ari, Anindya Sundar Panja |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71207 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |