Protective effects of rutin and quercetin against diazinon-induced toxicity in Wistar Rat Liver
Mastoureh Naddafi, Thumu Udayabhaskararao · 2026
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Description
Mastoureh Naddafi and Thumu Udayabhaskararao ask in 2026 whether two plant flavonoids can rescue rat livers poisoned by diazinon. The widely sprayed farm insecticide hits the liver first and blocks a key enzyme. Both candidate compounds, rutin and quercetin, are known antioxidants, so poisoned Wistar rats received each at the same dose. Liver markers of oxidative damage, antioxidant enzymes, and the blocked enzyme's activity were tracked against healthy controls.
Both compounds lowered the damage marker and improved the other readings in the reported results, yet quercetin clearly outperformed its partner. It restored antioxidant enzyme levels and the blocked enzyme to near control values, credited to stronger radical-scavenging power and better uptake by the body. The authors present quercetin as a promising candidate antidote for this poisoning while stressing that animal, cell, and clinical studies must come before any human use.
Catalog record
| CREATOR | Mastoureh Naddafi, Thumu Udayabhaskararao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48451 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |