Ex vivo evaluation of Newcastle disease virus to enhance natural killer cell function against acute myeloid leukemia cells
Shima Tavoosi, Soheila Rahgozar, Mohammad Ahmadvand, Mostafa Jarahian, Kayhan Azadmanesh · 2026
Read Ex vivo evaluation of Newcastle disease virus to enhance natural killer cell function against acute myeloid leukemia cells by Shima Tavoosi, Soheila Rahgozar, Mohammad Ahmadvand, Mostafa Jarahian, Kayhan Azadmanesh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13500703.txt.
Description
Shima Tavoosi and colleagues test in 2026 whether infecting leukaemia cells with a harmless bird virus can make them easier targets for the immune system's natural killer cells. Killer cells suit cell therapy because they attack tumours and tolerate donor mismatch, yet acute myeloid leukaemia often evades them. Laboratory lines and fresh patient cells, from new diagnoses and relapsed disease alike, were infected with a non-destroying Newcastle disease virus strain. They were then mixed with killer cells at several ratios while killing and immune signals were measured.
Infected leukaemia cells displayed a viral surface protein that acts as a danger flag for killer cell receptors in the reported experiments. Killer cells responded with stronger specific killing and released more interferon gamma plus the toxic proteins perforin and granzyme B. The authors propose sequencing treatment, virus first to sensitise the cancer, then an infusion of expanded killer cells to finish it.
Catalog record
| CREATOR | Shima Tavoosi, Soheila Rahgozar, Mohammad Ahmadvand, Mostafa Jarahian, Kayhan Azadmanesh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45083 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |