Reduced circulating 20-hydroxyeicosatetraenoic acid and ACE2 in acute coronary syndrome with exploratory cell-based observations
Ieva Čiapienė, Aistė Ivanauskienė, Nora Kupstytė-Krištaponė, Vaiva Lesauskaitė, Robertas Pranevičius, Gintarė Šakalytė, Daiva Stanislovaitienė, Cynthia Sithole, Vacis Tatarūnas · 2026
Read Reduced circulating 20-hydroxyeicosatetraenoic acid and ACE2 in acute coronary syndrome with exploratory cell-based observations by Ieva Čiapienė, Aistė Ivanauskienė, Nora Kupstytė-Krištaponė, Vaiva Lesauskaitė, Robertas Pranevičius, Gintarė Šakalytė, Daiva Stanislovaitienė, Cynthia Sithole, Vacis Tatarūnas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13500614.txt.
Description
Ieva Čiapienė and colleagues measure in 2026 two circulating molecules in patients whose coronary disease has turned acute, hunting for signals of a failing vessel-protection axis. One molecule, ACE2, anchors a calming branch of the hormone system that regulates blood pressure, while the other, called 20-HETE, is a fat-derived signal made by vessel cells. Blood from 122 patients with stable or acute coronary disease and 54 controls was assayed, and cell experiments probed how the two pathways interact.
Both molecules ran significantly lower in acute coronary syndrome than in stable disease or controls in the reported comparisons. The fat signal alone separated acute from stable patients with strong discrimination in curve analysis. Manipulating the hormone axis in cells shifted nitric oxide, inflammatory genes, and the enzyme making the fat signal. A functional receptor link completes a picture of one integrated vascular network breaking down during acute events.
Catalog record
| CREATOR | Ieva Čiapienė, Aistė Ivanauskienė, Nora Kupstytė-Krištaponė, Vaiva Lesauskaitė, Robertas Pranevičius, Gintarė Šakalytė, Daiva Stanislovaitienė, Cynthia Sithole, Vacis Tatarūnas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48476 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |