Artificial intelligence-enabled plaque characterization from coronary computed tomography establishes basis of angina in women with nonobstructive atherosclerosis
Rafal Wolny, Guadalupe Flores Tomasino, Kajetan Grodecki, Joel Lenell, Caroline Park, Rebekah Park, Jacek Kwiecinski, Osama Dasa, Vinicius Calsavara, Daniel S Berman, Piotr J Slomka, Matthew J Budoff, Eileen Handberg, Carl J Pepine, Leslee J Shaw, Janet Wei, Martha Gulati, C Noel Bairey Merz, Balaji · 2026
Read Artificial intelligence-enabled plaque characterization from coronary computed tomography establishes basis of angina in women with nonobstructive atherosclerosis by Rafal Wolny, Guadalupe Flores Tomasino, Kajetan Grodecki, Joel Lenell, Caroline Park, Rebekah Park, Jacek Kwiecinski, Osama Dasa, Vinicius Calsavara, Daniel S Berman, Piotr J Slomka, Matthew J Budoff, Eileen Handberg, Carl J Pepine, Leslee J Shaw, Janet Wei, Martha Gulati, C Noel Bairey Merz, Balaji (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13500560.txt.
Description
Rafal Wolny and others use AI plaque analysis from coronary CT to explain angina in women with non-obstructive coronary disease. In 2026, the WARRIOR trial substudy looks at baseline scans from 117 women with low blood flow and non-obstructive arteries. It quantifies noncalcified, low-attenuation, and calcified plaque across the coronary tree with a machine-learning low blood flow risk score.
Among 109 women with visible plaque, those with more severe angina carried higher total and noncalcified plaque burdens and lower calcified burden. They were younger, had higher blood fat, and less often took statins. Adjusted analysis linked noncalcified burden, low-attenuation burden, and low blood flow risk score to worse angina scores. High-risk plaque phenotypes, not just narrowing, appear to drive symptoms.
Catalog record
| CREATOR | Rafal Wolny, Guadalupe Flores Tomasino, Kajetan Grodecki, Joel Lenell, Caroline Park, Rebekah Park, Jacek Kwiecinski, Osama Dasa, Vinicius Calsavara, Daniel S Berman, Piotr J Slomka, Matthew J Budoff, Eileen Handberg, Carl J Pepine, Leslee J Shaw, Janet Wei, Martha Gulati, C Noel Bairey Merz, Balaji |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |