Premna odorata extract exhibits anti-inflammatory activity via suppression of NLRP3 inflammasome
Jaehyeok Lee, Seyoung Kim, Seongjong Lee, Hangyeol Lee, Hyeyun Yang, Seoyeon Jang, Sojin Yun, Ja Hyang Cho, Man S. Kim, Hyung Won Ryu, Jung Hee Kim, Dong-Keun Yi, Soo-Yong Kim, SangHo Choi, Sang Woo Lee, Md. Salah Uddin, Hyoung-Geun Kim, Yoonsung Lee, Yong Hwan Park · 2026
Read Premna odorata extract exhibits anti-inflammatory activity via suppression of NLRP3 inflammasome by Jaehyeok Lee, Seyoung Kim, Seongjong Lee, Hangyeol Lee, Hyeyun Yang, Seoyeon Jang, Sojin Yun, Ja Hyang Cho, Man S. Kim, Hyung Won Ryu, Jung Hee Kim, Dong-Keun Yi, Soo-Yong Kim, SangHo Choi, Sang Woo Lee, Md. Salah Uddin, Hyoung-Geun Kim, Yoonsung Lee, Yong Hwan Park (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13500559.txt.
Description
Jaehyeok Lee leads a 2026 laboratory study of a Philippine medicinal plant, Premna odorata, known locally as alagaw and used traditionally for inflamed airways. Molecular proof for its effects was lacking, so the team tested its extract against the NLRP3 inflammasome, an intracellular alarm complex whose product, interleukin-1 beta, drives many inflammatory diseases. Two macrophage cell lines were primed and then triggered with standard activators.
The extract cut interleukin-1 beta release triggered through the target complex while leaving two sibling alarm complexes untouched, showing selectivity in the reported assays. It blocked assembly of the complex by preventing its adaptor protein from clumping, without killing cells or changing reactive oxygen levels. In a zebrafish inflammation model, the extract reduced inflammatory cell infiltration, giving the traditional remedy a defined molecular basis and a scaffold for targeted drug design.
Catalog record
| CREATOR | Jaehyeok Lee, Seyoung Kim, Seongjong Lee, Hangyeol Lee, Hyeyun Yang, Seoyeon Jang, Sojin Yun, Ja Hyang Cho, Man S. Kim, Hyung Won Ryu, Jung Hee Kim, Dong-Keun Yi, Soo-Yong Kim, SangHo Choi, Sang Woo Lee, Md. Salah Uddin, Hyoung-Geun Kim, Yoonsung Lee, Yong Hwan Park |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44305 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |