Preparation, characterization and in-vivo evaluation of nanoemulsion based hydrogel of ferulic acid in imiquimod-induced psoriasis in rats
Nosheen Naseer, Sairah Hafeez Kamran, Misbah Sultana, Saiqa Ishtiaq, Farhan Siddique, Muhammad Farhan Sohail, M. Ismail Mastoi · 2026
Read Preparation, characterization and in-vivo evaluation of nanoemulsion based hydrogel of ferulic acid in imiquimod-induced psoriasis in rats by Nosheen Naseer, Sairah Hafeez Kamran, Misbah Sultana, Saiqa Ishtiaq, Farhan Siddique, Muhammad Farhan Sohail, M. Ismail Mastoi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13500538.txt.
Description
Nosheen Naseer and co-authors formulate in 2026 a gel carrying ferulic acid in nanoemulsion droplets for treating psoriasis-like skin inflammation, testing it in rats. Ferulic acid, a plant antioxidant, dissolves poorly in water, which limits skin delivery, so the team built tiny oil droplets with ultrasound and set them into a hydrogel. Disease was triggered on shaved backs with imiquimod cream for seven days in four of five small groups of male Wistar rats, then the gel was applied to the treatment group.
Droplet size sat in the colloidal range with even distribution and stable charge, and the gel spread and acidity suited skin use in their characterisation. Treated rats showed sharply lower inflammatory and oxidative markers than untreated diseased rats, and spleen swelling eased. Tissue sections showed psoriatic changes greatly reduced, with docking simulations supporting a direct interaction with a key inflammatory cytokine.
Catalog record
| CREATOR | Nosheen Naseer, Sairah Hafeez Kamran, Misbah Sultana, Saiqa Ishtiaq, Farhan Siddique, Muhammad Farhan Sohail, M. Ismail Mastoi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85711 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |