ALKBH2 promotes the Warburg effect and bladder cancer progression under hypoxic conditions via the PI3K/AKT pathway
Zhangjie Yang, Jinhu Ma, Ziyang Qiang, Wenhao Xie, Liang Jiao, Zhenxing Hu, Tiange Zhang, Limei Zhang, Jinqiong Lv, Fangqian Yue, Guojun Chen · 2026
Read ALKBH2 promotes the Warburg effect and bladder cancer progression under hypoxic conditions via the PI3K/AKT pathway by Zhangjie Yang, Jinhu Ma, Ziyang Qiang, Wenhao Xie, Liang Jiao, Zhenxing Hu, Tiange Zhang, Limei Zhang, Jinqiong Lv, Fangqian Yue, Guojun Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13500419.txt.
Description
Zhangjie Yang and colleagues investigate in 2026 a DNA repair enzyme that appears to double as a metabolic driver in bladder cancer. The enzyme, ALKBH2, normally reverses chemical damage to DNA, yet tumours often rewire energy use toward sugar fermentation even under low oxygen, a pattern called the Warburg effect. Comparing cancer tissue with matched normal tissue and engineering cell lines to raise or silence the enzyme let the team test its role in growth and metabolism.
Extra enzyme made cancer cells proliferate, migrate, invade, and form colonies more strongly, while silencing it reversed those behaviours and shrank tumours in mouse graft models. Mechanistic work showed the enzyme strips a chemical mark from the RNA of a tumour suppressor gene, destabilising it and releasing a major growth signalling pathway under low-oxygen conditions. The authors propose the enzyme as a therapeutic target worth pursuing.
Catalog record
| CREATOR | Zhangjie Yang, Jinhu Ma, Ziyang Qiang, Wenhao Xie, Liang Jiao, Zhenxing Hu, Tiange Zhang, Limei Zhang, Jinqiong Lv, Fangqian Yue, Guojun Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58629 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |