Hormonal profiles of men with highly elevated SHBG and primary testicular dysfunction support free hormone hypothesis
Thiago Gagliano-Jucá, Ishika Puri, Gabriel Ramirez-Rivera, Skand Shekhar, Rodrigo J Valderrábano, Anna L Goldman, Yusnie Memish-Beleva, Mary Weiss, Yili Valentine Shang, Karol M Pencina, Ravi Jasuja, Shalender Bhasin · 2026
Read Hormonal profiles of men with highly elevated SHBG and primary testicular dysfunction support free hormone hypothesis by Thiago Gagliano-Jucá, Ishika Puri, Gabriel Ramirez-Rivera, Skand Shekhar, Rodrigo J Valderrábano, Anna L Goldman, Yusnie Memish-Beleva, Mary Weiss, Yili Valentine Shang, Karol M Pencina, Ravi Jasuja, Shalender Bhasin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13500193.txt.
Description
A peer-reviewed research article from Europe PMC (2026). ContextFree hormone hypothesis (FHH) posits that free testosterone crosses plasma membrane to activate intracellular signaling and is biologically active fraction of circulating testosterone. Widely accepted in other fields, FHH has been debated in andrology.ObjectiveTo disentangle the roles of free and total testosterone, we studied men with greatly elevated sex hormone-binding globulin (SHBG) levels and primary hypogonadism, who had marked divergence in total and free testosterone concentrations, in whom elevated gonadotropins provided independent evidence of primary testicular insufficiency.DesignProspective hormonal evaluation of men with
Catalog record
| CREATOR | Thiago Gagliano-Jucá, Ishika Puri, Gabriel Ramirez-Rivera, Skand Shekhar, Rodrigo J Valderrábano, Anna L Goldman, Yusnie Memish-Beleva, Mary Weiss, Yili Valentine Shang, Karol M Pencina, Ravi Jasuja, Shalender Bhasin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |