Indirect Treatment Comparison of Tezepelumab Versus Other Biologics in Severe Chronic Rhinosinusitis with Nasal Polyps: A Systematic Literature Review and Network Meta-analysis
Joseph K. Han, Joaquim Mullol, Claire Hopkins, Oliver Pfaar, Martin Desrosiers, Jason Steenkamp, Danny Gibson, Santiago Zuluaga Sanchez, Andrew Foster, Christopher S. Ambrose · 2026
Read Indirect Treatment Comparison of Tezepelumab Versus Other Biologics in Severe Chronic Rhinosinusitis with Nasal Polyps: A Systematic Literature Review and Network Meta-analysis by Joseph K. Han, Joaquim Mullol, Claire Hopkins, Oliver Pfaar, Martin Desrosiers, Jason Steenkamp, Danny Gibson, Santiago Zuluaga Sanchez, Andrew Foster, Christopher S. Ambrose (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13499838.txt.
Description
Joseph K Han and co-authors compare in 2026 tezepelumab with rival antibody drugs and with sinus surgery for severe chronic rhinosinusitis with nasal polyps. The long-term sinus disease grows tissue that blocks smell and breathing. No head-to-head trials exist, so the team ran indirect comparisons through a network meta-analysis, a method that links treatments through shared trial comparators. Outcomes at one year covered polyp size, congestion, smell, quality-of-life scores, imaging, and need for surgery or steroid courses.
Tezepelumab matched dupilumab on nearly every endpoint and was linked to a lower share of patients needing polyp surgery in the comparison figures. It consistently outperformed two other antibodies and placebo, and beat a fourth antibody on most shorter-term outcomes. Surgery ranked highest for shrinking polyps in sensitivity checks, while tezepelumab led on the remaining endpoints, a pattern the authors offer for treatment planning.
Catalog record
| CREATOR | Joseph K. Han, Joaquim Mullol, Claire Hopkins, Oliver Pfaar, Martin Desrosiers, Jason Steenkamp, Danny Gibson, Santiago Zuluaga Sanchez, Andrew Foster, Christopher S. Ambrose |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49022 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |