Central vein sign and paramagnetic rim lesions in pediatric-onset multiple sclerosis: a systematic review and meta-analysis
Anna de Mauro, Rosa Cortese, Giulia Fadda, Nicola De Stefano, Ludwig Kappos, Maria Pia Sormani, Brenda Banwell, Cristina Granziera, Alessandro Cagol · 2026
Read Central vein sign and paramagnetic rim lesions in pediatric-onset multiple sclerosis: a systematic review and meta-analysis by Anna de Mauro, Rosa Cortese, Giulia Fadda, Nicola De Stefano, Ludwig Kappos, Maria Pia Sormani, Brenda Banwell, Cristina Granziera, Alessandro Cagol (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13499817.txt.
Description
De Mauro and co-authors pool evidence on two MRI signs in children and teens whose multiple sclerosis began early. The signs, a vein running through a lesion's center and an iron rim around some lesions, entered adult diagnostic rules in 2024 for their accuracy. Their 2026 review and meta-analysis gathers eleven studies of young patients.
Across studies, about seventy two percent of young patients had at least one rim lesion. About fifty eight percent of lesions showed the central vein, and two thirds of patients passed a standard vein threshold, though results swung widely between studies. Rim lesions looked highly specific when compared against look alike diseases, while vein data stayed thin. The authors call for child focused accuracy studies before these signs guide young diagnoses.
Catalog record
| CREATOR | Anna de Mauro, Rosa Cortese, Giulia Fadda, Nicola De Stefano, Ludwig Kappos, Maria Pia Sormani, Brenda Banwell, Cristina Granziera, Alessandro Cagol |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |