Chronic traumatic encephalopathy: A devastating legacy of repetitive concussion
Sunghyun Jun, Colleen Marie Arrasmith, Volha Liaudanskaya · 2026
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Description
Sunghyun Jun, Colleen Marie Arrasmith, and Volha Liaudanskaya draw together in 2026 what is known about chronic traumatic encephalopathy, a brain degeneration linked to repeated head impacts. Connecting years of knocks to later disease has lacked a single clear mechanism. Their synthesis spans population studies, brain tissue work, and clinical reports to build one chain from exposure to decline.
Initial injury sets off energy failure in brain cells, inflammation, and damage to nerve fibres across several cell types. Over time those processes promote misfolded proteins, including tau, which gathers in a distinctive pattern around small blood vessels deep in the brain's folds. Symptoms vary widely and current scans and fluid tests lack precision, while no single lab model captures the full course, leaving detection during life as a central research need.
Catalog record
| CREATOR | Sunghyun Jun, Colleen Marie Arrasmith, Volha Liaudanskaya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79050 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |