Organometallic Chemistry Approach to Peptide Tricycles
Nima Adhami, Michael J.P. Rebelo, Rebecca A. Jenkins, Eileen J. Olivares, Rachel R. Ogorzalek Loo, Songrong Qu, Melanie J. Olivares, Reanne J. Coutinho, Evan A. Doud, Tyler A. Kerr, Austin D. Ready, Yueying Wang, Brendan J. Mahoney, Robert T. Clubb, Joseph A. Loo, Jose A. Rodriguez, Alexander M. Spokoyny · 2026
Read Organometallic Chemistry Approach to Peptide Tricycles by Nima Adhami, Michael J.P. Rebelo, Rebecca A. Jenkins, Eileen J. Olivares, Rachel R. Ogorzalek Loo, Songrong Qu, Melanie J. Olivares, Reanne J. Coutinho, Evan A. Doud, Tyler A. Kerr, Austin D. Ready, Yueying Wang, Brendan J. Mahoney, Robert T. Clubb, Joseph A. Loo, Jose A. Rodriguez, Alexander M. Spokoyny (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13495551.txt.
Description
Adhami and colleagues use gold chemistry to snap peptides into three ring structures, a shape class that drug hunters prize but struggle to make. Stiffened peptides grip protein surfaces and survive digestion longer than floppy ones. Their 2026 study uses a reagent carrying four gold centers on one core. It latches fast onto cysteine, the sulfur bearing amino acid, at four points along a peptide chain. The chain folds into a tricycle in one step.
The reaction finished in under five minutes at dilute concentrations. It worked whatever pattern the cysteines followed, giving a library of tricycles in moderate yields. Around a glow prone core used in lighting materials, the peptides became fluorescent rings that kept glowing in solution, rare for that family. Tested on cells, the tricycles marked debris with high selectivity. The team frames the method as a way to build architectures for probes and drug leads.
Catalog record
| CREATOR | Nima Adhami, Michael J.P. Rebelo, Rebecca A. Jenkins, Eileen J. Olivares, Rachel R. Ogorzalek Loo, Songrong Qu, Melanie J. Olivares, Reanne J. Coutinho, Evan A. Doud, Tyler A. Kerr, Austin D. Ready, Yueying Wang, Brendan J. Mahoney, Robert T. Clubb, Joseph A. Loo, Jose A. Rodriguez, Alexander M. Spokoyny |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |