Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts

Brooke D Conway Kleven, Lung-Chang Chien, Dana Surwill, Michael L Alosco, Jennifer V Wethe, Yorghos Tripodis, Charles H Adler, Martha E Shenton, Ofer Pasternak, Douglas I Katz, Elaine Peskind, Laura J Balcer, Inga K Koerte, Jesse Mez, Eric M Reiman, Robert C Cantu, Robert A Stern, Henrik Zetterberg, Charles Bernick, Jeffrey L Cummings · 2026

Read Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts by Brooke D Conway Kleven, Lung-Chang Chien, Dana Surwill, Michael L Alosco, Jennifer V Wethe, Yorghos Tripodis, Charles H Adler, Martha E Shenton, Ofer Pasternak, Douglas I Katz, Elaine Peskind, Laura J Balcer, Inga K Koerte, Jesse Mez, Eric M Reiman, Robert C Cantu, Robert A Stern, Henrik Zetterberg, Charles Bernick, Jeffrey L Cummings (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13495526.txt.

Description

Brooke D Conway Kleven leads a large team testing, in a 2026 study, whether thinking scores, blood markers, and brain scans together identify traumatic encephalopathy syndrome in athletes. The syndrome flags people at risk of CTE, the brain disease tied to repeated head impacts, but diagnosis still rests on symptoms alone. The team studied 158 professional fighters and 149 former football players from two long-running projects.

They built three combined scores, one each for cognition, blood markers of brain injury, and scan measures of brain structure. Models using all three beat any single score at sorting who met the syndrome criteria in both groups. Scans added most for fighters, while blood markers spoke loudest for football players. The authors say the syndrome carries a shared biological fingerprint across sports, a step toward tests that rest on more than symptoms.

Catalog record

CREATORBrooke D Conway Kleven, Lung-Chang Chien, Dana Surwill, Michael L Alosco, Jennifer V Wethe, Yorghos Tripodis, Charles H Adler, Martha E Shenton, Ofer Pasternak, Douglas I Katz, Elaine Peskind, Laura J Balcer, Inga K Koerte, Jesse Mez, Eric M Reiman, Robert C Cantu, Robert A Stern, Henrik Zetterberg, Charles Bernick, Jeffrey L Cummings
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE55776
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13495526

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