Three-year outcomes of customized transepithelial corneal cross-linking with oxygen supplementation in keratoconus

Takashi Kojima, Yingsong Lin, Asahi Hishida, Tomoaki Nakamura · 2026

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Description

Takashi Kojima, Yingsong Lin, Asahi Hishida, and Tomoaki Nakamura report, in a 2026 study, three-year results for a gentle form of corneal cross-linking in keratoconus. In this disease the cornea thins and bulges forward, blurring sight. Cross-linking stiffens it, yet the standard method strips the surface layer; this custom version works through the intact surface with added oxygen and a tailored pattern.

The team followed 74 patients with 90 treated eyes for at least three years. From year one, uncorrected sight and the steepest cornea measure improved and held. Optical flaws of the cornea eased step by step. The cornea thinned slightly at its peak and thinnest points, a change watched closely. No infections or haze appeared. The authors call the method a possible stabilizer, while asking for randomized trials to weigh it against standard care.

Catalog record

CREATORTakashi Kojima, Yingsong Lin, Asahi Hishida, Tomoaki Nakamura
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE31361
LICENSEhttps://creativecommons.org/licenses/by/4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/article/MED/PMC13495439

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