Efficacy and safety of desogestrel/ethinylestradiol 150/20 flexible extended regimen (FREEDOM 150/20) in dysmenorrhea: phase 3 study in Japan
Kaori Koga, Daniela Colaci, Madeline Grigg, Daisuke Goto, Tinghui Yu, Mikio Momoeda · 2026
Read Efficacy and safety of desogestrel/ethinylestradiol 150/20 flexible extended regimen (FREEDOM 150/20) in dysmenorrhea: phase 3 study in Japan by Kaori Koga, Daniela Colaci, Madeline Grigg, Daisuke Goto, Tinghui Yu, Mikio Momoeda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13494605.txt.
Description
Kaori Koga and colleagues report a 2026 phase 3 trial in Japan of a flexible hormone pill routine for painful periods, known as dysmenorrhea. The pill pairs desogestrel with a low dose of ethinylestradiol. Rather than fixed monthly cycles, users take the pill for 24 to 80 days in a row, then pause for four days, choosing the rhythm themselves. The trial ran at 21 centers with a blinded phase and an open follow-up.
The study enrolled 211 women with regular cycles and period pain, giving most the drug and the rest a placebo. Pain scores fell far more on the drug through day 84, and days of strong pain shrank. Over eighty percent on the drug reported feeling better, against under thirty percent on placebo, and satisfaction scores ran higher. Bleeding between periods, colds, and nausea were the most common side effects, and no deaths occurred.
Catalog record
| CREATOR | Kaori Koga, Daniela Colaci, Madeline Grigg, Daisuke Goto, Tinghui Yu, Mikio Momoeda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37559 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |