Downregulation of Lgals3 Alleviates Inflammatory Response and Apoptosis in a Mouse Model of Cerebral Ischemia/Reperfusion Injury
Zhaodan Gan, Haifang Lai, Yun Yang, Jun Lu, Wen Zhang, Jianqiu Xiao, Guangxu Xu · 2026
Read Downregulation of Lgals3 Alleviates Inflammatory Response and Apoptosis in a Mouse Model of Cerebral Ischemia/Reperfusion Injury by Zhaodan Gan, Haifang Lai, Yun Yang, Jun Lu, Wen Zhang, Jianqiu Xiao, Guangxu Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13494508.txt.
Description
Gan and colleagues investigated a sugar-binding protein called Lgals3 in brain injury that follows restored blood flow after stroke, in a 2026 mouse study. Restoring circulation saves tissue but triggers inflammation and cell death, worsening damage. Mining gene-expression data flagged Lgals3 as increased after this ischemia-reperfusion injury, and the team confirmed the rise in mice whose cerebral artery was blocked.
Gan delivered a virus carrying a silencing sequence against Lgals3 into the mice weeks before the artery blockage. Silenced mice developed smaller brain regions of damage, scored better on neurological tests, and lost fewer neurons to cell death. Brain levels of three inflammatory messengers fell while a messenger rose. The team showed Lgals3 binds TLR4, an immune alarm receptor, and that silencing quieted the signaling chain running from that receptor to the inflammation switch. They propose Lgals3 as a drug target for limiting reperfusion damage after stroke.
Catalog record
| CREATOR | Zhaodan Gan, Haifang Lai, Yun Yang, Jun Lu, Wen Zhang, Jianqiu Xiao, Guangxu Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |