Sciatic denervation differentially remodels skeletal muscle and deep fascia in the lower limb of male mice
Shun Otsuka, Yuki Tamaki, Kanae Umemoto, Naoyuki Hatayama, Munekazu Naito · 2026
Read Sciatic denervation differentially remodels skeletal muscle and deep fascia in the lower limb of male mice by Shun Otsuka, Yuki Tamaki, Kanae Umemoto, Naoyuki Hatayama, Munekazu Naito (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13494361.txt.
Description
Otsuka and colleagues examined what happens to the deep fascia when a leg nerve is cut, in a 2026 mouse study. The fascia is the dense connective sheet wrapping muscles and transmitting their force. Muscle wasting after denervation is documented, but the fascia's response was unknown. Five to six mice had the sciatic nerve severed on one side or sham surgery, and muscle and fascia were examined fourteen days later.
Otsuka found the shin muscle wasting as expected, switching on inflammatory and scarring genes while switching off a growth factor. The fascia responded differently: it thickened by about half, raised inflammatory and scarring signals, produced more of two collagen types, and shifted the balance toward the more flexible collagen form. The authors conclude denervation remodels muscle and fascia in coordinated but tissue-specific ways. Rehabilitation after nerve injury must reckon with a stiffening fascial envelope, not the shrinking muscle inside it.
Catalog record
| CREATOR | Shun Otsuka, Yuki Tamaki, Kanae Umemoto, Naoyuki Hatayama, Munekazu Naito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |