Pseudouridine synthase 7 as a context-specific therapeutic target in cancer
Karen Abundiz-Yañez, Luis Córdova-Bahena, Nohemí Salinas-Jazmín, Angel J Trejo-León, Marco A Velasco-Velázquez · 2026
Read Pseudouridine synthase 7 as a context-specific therapeutic target in cancer by Karen Abundiz-Yañez, Luis Córdova-Bahena, Nohemí Salinas-Jazmín, Angel J Trejo-León, Marco A Velasco-Velázquez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13494219.txt.
Description
Karen Abundiz-Yañez and four co-authors review an RNA-editing enzyme as a possible cancer target, in a paper dated 2026. The enzyme, called PUS7, rewrites one letter of RNA into a variant form. Depending on the cancer, that editing can speed tumors up or slow them down.
In brain, pancreas, nerve, liver, and colon cancers, the enzyme helps tumors grow, spread, and resist stress. In colon cancer it can also drive growth without its editing action, by partnering with other proteins. Yet in stomach and one thyroid cancer it acts as a brake, trimming messages that fuel aggression. Because its role flips by setting, the authors urge care: blocking it could help in one cancer and harm in another. Mapping when it helps or hurts comes first.
Catalog record
| CREATOR | Karen Abundiz-Yañez, Luis Córdova-Bahena, Nohemí Salinas-Jazmín, Angel J Trejo-León, Marco A Velasco-Velázquez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |