Loss of palmitoylation impacts the interaction between the organic anion transporting polypeptide (OATP) 1B1 and OATP1B3
Cecilia E. Villanueva, Whitney M. Nolte, Priscilla Flores-Ascencio, Bruno Hagenbuch · 2026
Read Loss of palmitoylation impacts the interaction between the organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 by Cecilia E. Villanueva, Whitney M. Nolte, Priscilla Flores-Ascencio, Bruno Hagenbuch (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13494216.txt.
Description
Cecilia Villanueva and co-authors study a fatty tag that two liver transport proteins carry in a 2026 paper. The transporters pull many drugs, such as antibiotics and statins, into liver cells. Chemical tags added after a protein is built can change where it sits and what it touches.
The team pinned the tag, a sixteen-carbon fatty acid, to one specific site shared by both transporters. Removing the tag did not change each transporter's own uptake work or its presence at the cell surface. It did weaken how the two transporters interact when they are present together. The authors conclude the tag's role here is social: it manages partnership between the proteins rather than solo performance.
Catalog record
| CREATOR | Cecilia E. Villanueva, Whitney M. Nolte, Priscilla Flores-Ascencio, Bruno Hagenbuch |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |