Leveraging Single-Cell and Spatial Transcriptomics in Gut Nutrition and Mucosal Immunology
Jiaxing Yang, Nan Gao · 2026
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Description
Jiaxing Yang and Nan Gao write a 2026 editorial on how new gene-reading tools are reshaping study of the gut, its food, and its immune defenses. The gut lining meets food, helpful microbes, and germs at once, so its cells talk constantly with immune cells nearby. Single-cell methods read gene activity one cell at a time, while spatial methods keep track of where each cell sits.
The authors point to recent studies that used these tools to map gut cell types, spot rare cells, and trace signals between the lining and immune cells during infection and bowel inflammation. They argue that adding spatial maps and live labeling in animals can show true cell-to-cell contact, not just likely signals. That detail could reveal how nutrients steer gut immunity and where diet-based treatments might act.
Catalog record
| CREATOR | Jiaxing Yang, Nan Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9658 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |