A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial)
Alba X. Realpe, Jade Eloise Norris, Ava Lorenc, Leonora Cotton, Zoe Morgan, Aws Sadik, Dheeraj Rai, Nicola Mills, David Carmichael · 2026
Read A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial) by Alba X. Realpe, Jade Eloise Norris, Ava Lorenc, Leonora Cotton, Zoe Morgan, Aws Sadik, Dheeraj Rai, Nicola Mills, David Carmichael (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13494128.txt.
Description
Alba X Realpe leads a 2026 qualitative study on whether taking part in a large drug trial felt acceptable to autistic adults. The STRATA trial tests sertraline, a common antidepressant, for anxiety in autistic adults, a group often left out of such research. The team interviewed 64 autistic adults at varied stages of the trial and sorted their views using a standard framework for judging acceptability.
Most participants found the blinded trial low in burden, fair in design, and clear in purpose. Views shifted between what people expected before joining and what they felt once inside the trial, so acceptability proved fluid rather than fixed. People weighed gains, effort, and their own confidence in unlike ways. The authors say acceptability grows when autistic people help shape a trial from the start, when study materials stay easy to use, and when staff keep in close touch.
Catalog record
| CREATOR | Alba X. Realpe, Jade Eloise Norris, Ava Lorenc, Leonora Cotton, Zoe Morgan, Aws Sadik, Dheeraj Rai, Nicola Mills, David Carmichael |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59102 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |