Sympathetic signaling activation alleviated acute respiratory distress syndrome via the HDC/SLC7A11 axis in lipopolysaccharide-induced macrophages
Xing Lv, Chenhao Jiang, Xu Zhang, Zhengqi Wu, Xuxia Wei, Yang Zhao, Jianhao Zhang, Xuegang Zhao, Lu Han, Yufeng He, Jianrong Liu, Yujun Zhang, Yuling An, Xiaomeng Yi, Yingcai Zhang, Xin Sui, Huimin Yi · 2026
Read Sympathetic signaling activation alleviated acute respiratory distress syndrome via the HDC/SLC7A11 axis in lipopolysaccharide-induced macrophages by Xing Lv, Chenhao Jiang, Xu Zhang, Zhengqi Wu, Xuxia Wei, Yang Zhao, Jianhao Zhang, Xuegang Zhao, Lu Han, Yufeng He, Jianrong Liu, Yujun Zhang, Yuling An, Xiaomeng Yi, Yingcai Zhang, Xin Sui, Huimin Yi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13493966.txt.
Description
Xing Lv leads a seventeen-author team reporting in 2026 that the body's own stress signal can protect lungs in acute respiratory distress syndrome, a flooding inflammation that suffocates patients. The messenger norepinephrine was tested on lung macrophages poisoned with bacterial toxin in dishes, and its receptor's activator drug, salbutamol, was given to septic mice. The question was whether nerve signals could stop a rust-like cell death called ferroptosis.
Treated macrophages kept their mitochondria intact, limited fat oxidation damage, and survived better, powered by two antioxidant defenders switched on downstream. Blocking the receptor or the enzyme HDC erased the protection, pinning the mechanism down. In mice, salbutamol raised the same defenders in lung macrophages and eased tissue injury, nominating the pathway as a drug target.
Catalog record
| CREATOR | Xing Lv, Chenhao Jiang, Xu Zhang, Zhengqi Wu, Xuxia Wei, Yang Zhao, Jianhao Zhang, Xuegang Zhao, Lu Han, Yufeng He, Jianrong Liu, Yujun Zhang, Yuling An, Xiaomeng Yi, Yingcai Zhang, Xin Sui, Huimin Yi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65239 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |