Short-chain fatty acids of intestinal origin attenuate protein-bound uremic toxins in patients with chronic kidney disease by protecting the intestinal barrier: a pooled analysis of multiple studies with individualized intervention strategies
Mengzhe Wang, Yumeng Li, Zixuan Fu, Yuheng Liu, Yingge He, Changqing Gao, Yaling Li, Huina Wu, Yongchang Yuan, Liyu Chen, Liqi Li · 2026
Read Short-chain fatty acids of intestinal origin attenuate protein-bound uremic toxins in patients with chronic kidney disease by protecting the intestinal barrier: a pooled analysis of multiple studies with individualized intervention strategies by Mengzhe Wang, Yumeng Li, Zixuan Fu, Yuheng Liu, Yingge He, Changqing Gao, Yaling Li, Huina Wu, Yongchang Yuan, Liyu Chen, Liqi Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491836.txt.
Description
Mengzhe Wang leads an eleven-author team pooling in 2026 four studies on gut-derived short-chain fatty acids and the stubborn toxins that accumulate in chronic kidney disease. Protein-bound toxins resist dialysis because they hitch onto blood proteins, so cutting their production in the gut is attractive. The combined data held 320 kidney patients and 53 healthy controls.
Patients carried fewer of the bacteria that make these fatty acids, and one acid, butyrate, moved opposite to toxin levels in the blood. Roughly a third of the protective effect ran through a healthier intestinal barrier, which leaks fewer toxins into circulation. Diets pairing synbiotics or low protein with high fiber cut toxins most, especially in advanced disease stages. The authors promote gut-focused care as a complement to dialysis.
Catalog record
| CREATOR | Mengzhe Wang, Yumeng Li, Zixuan Fu, Yuheng Liu, Yingge He, Changqing Gao, Yaling Li, Huina Wu, Yongchang Yuan, Liyu Chen, Liqi Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77478 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |