Spinal low-grade ependymal tumors harboring telomerase reverse transcriptase promoter mutation and chromosome 7 gain with methylation profile of spinal subependymoma
Yoshitaka Nagashima, Junya Yamaguchi, Yusuke Nishimura, Masafumi Seki, Seiji Yamada, Sachi Maeda, Eisuke Tsukamoto, Ryo Yamamoto, Yuhei Takido, Keisuke Kimura, Fumiharu Ohka, Kennosuke Karube, Ryuta Saito · 2026
Read Spinal low-grade ependymal tumors harboring telomerase reverse transcriptase promoter mutation and chromosome 7 gain with methylation profile of spinal subependymoma by Yoshitaka Nagashima, Junya Yamaguchi, Yusuke Nishimura, Masafumi Seki, Seiji Yamada, Sachi Maeda, Eisuke Tsukamoto, Ryo Yamamoto, Yuhei Takido, Keisuke Kimura, Fumiharu Ohka, Kennosuke Karube, Ryuta Saito (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491719.txt.
Description
Yoshitaka Nagashima leads a thirteen-author team describing in 2026 two spinal cord tumors that defied tidy classification. Both growths were low-grade ependymal tumors in elderly patients, with tidy borders typical of a gentler subtype called subependymoma. Yet under the microscope they lacked that subtype's signature cell clusters, showed an unexpected marker protein, and had growth rates a little higher than expected.
Chemical profiling of DNA methylation placed both tumors at the edge of the subependymoma class, with only modest confidence scores. Each tumor also carried a mutation in the promoter of the telomerase gene TERT and an extra copy of chromosome 7. Current rules therefore label them grade 2 ependymal tumors wearing a subependymoma-like profile. The authors say such mismatches, increasingly noticed, will force classification systems to adapt.
Catalog record
| CREATOR | Yoshitaka Nagashima, Junya Yamaguchi, Yusuke Nishimura, Masafumi Seki, Seiji Yamada, Sachi Maeda, Eisuke Tsukamoto, Ryo Yamamoto, Yuhei Takido, Keisuke Kimura, Fumiharu Ohka, Kennosuke Karube, Ryuta Saito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28858 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |