Circadian gatekeepers of the gut–brain–immune axis: implications for neuroinflammation and neurodegeneration
Wai-Yin Cheng, Po-Lam Chan, Man-Ka Chan, Jiaying Xu, Ka-Hing Wong, Raymond Chuen-Chung Chang · 2026
Read Circadian gatekeepers of the gut–brain–immune axis: implications for neuroinflammation and neurodegeneration by Wai-Yin Cheng, Po-Lam Chan, Man-Ka Chan, Jiaying Xu, Ka-Hing Wong, Raymond Chuen-Chung Chang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491710.txt.
Description
Wai-Yin Cheng and five co-authors review in 2026 how daily body clocks govern the conversation among gut, brain, and immune system, and what happens when those clocks slip. Circadian rhythms, roughly twenty-four-hour cycles driven by light and dark, shape sleep, metabolism, and immunity. The reviewers trace how disrupted rhythms alter gut microbes and immune signaling in ways that may feed brain inflammation and degeneration.
Sleep disturbance often appears before memory symptoms in dementia, and poor sleep lets amyloid-beta, a protein linked to Alzheimer's disease, build up. Shift work that scrambles internal timing has likewise been tied to higher risk of cognitive problems. The authors propose that restoring healthy daily rhythms, and the microbial rhythms that follow them, could become a strategy to slow neurodegenerative disease.
Catalog record
| CREATOR | Wai-Yin Cheng, Po-Lam Chan, Man-Ka Chan, Jiaying Xu, Ka-Hing Wong, Raymond Chuen-Chung Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64057 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |