Prognostic significance of therapy-induced senescence and SASP dynamics in acute myeloid leukemia: a retrospective cohort study
Bing Ma, Lihong Zhang · 2026
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Description
Bing Ma and Lihong Zhang examine in 2026 whether cells aged prematurely by chemotherapy predict relapse in acute myeloid leukemia. Treatment forces some leukemia cells into senescence, a halted state, yet those cells release signals that may shelter surviving cancer. The single-center study followed 128 newly diagnosed patients treated with standard induction chemotherapy between 2019 and 2023.
Bone marrow checks before and after treatment measured aging markers such as p16INK4a and p21Cip1 plus the secreted signals IL-6 and IL-8. Patients with a high senescence burden after treatment relapsed sooner and died earlier, with median survival roughly a year shorter than the low-burden group. High IL-6 and high p16INK4a each independently predicted poor outcomes. The authors propose drugs that clear senescent cells as a future addition to leukemia care.
Catalog record
| CREATOR | Bing Ma, Lihong Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24558 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |